Taconic Biosciences unveils Random Integration Transgenic animal model generation solution

KUALA LUMPUR, Dec 4 -- Taconic Biosciences, a global leader in providing drug discovery animal model solutions, has launched the new ExpressMODEL®: Random Integration Transgenic (RITg) service, which reduces animal model generation costs and timeline.

According to a statement, the technique used to generate RITg models produces an initial litter where the individual founder animals may or may not carry and/or express the intended genetic feature.

Traditionally, each animal must be bred for several generations to determine which one(s) produce the desired outcome.

This process adds considerable time and money to a project. In an industry compelled to reduce the timeline and cost of bringing new therapeutics to the world, ExpressMODEL®: RITg alleviates this burden.

Instead of breeding each founder animal and characterising its offspring, ExpressMODEL®: RITg analyses transgene expression and animal fertility in the first litter, whereby this approach mitigates several risks inherent to RITg model generation.

“The ExpressMODEL® portfolio started with Taconic leveraging its expertise and capabilities in a new way to accelerate the model generation process,” said Taconic vice-president of scientific services, Dr John Couse.

“ExpressMODEL®: RITg continues that commitment, combining Taconic’s strong model generation know-how with expertise in sperm cryopreservation, in vitro fertilisation, and transgene analysis to eliminate the risks associated with this gene editing technique.”

Taconic is a fully-licensed provider of rodent model generation services and has over 20 years of model generation experience, providing gene inactivation, gene mutation or replacement, transgene expression, RNAi, and gene editing.

-- BERNAMA